Phthalimidoacetaldehyde diethyl acetal

Phthalimidoacetaldehyde diethyl acetal - Names and Identifiers

Name	Phthalimidoacetaldehyde diethyl acetal
Synonyms	LABOTEST-BB LT00454122 N-(2,2-DIETHOXYETHYL)PHTHALIMIDE phthalimido-acetaldehyde hydrate Phthalimidoacetaldehyde diethyl acetal PHTHALIMIDOACETALDEHYDE DIETHYL ACETAL 2-PHTHALIMIDOACETALDEHYDE DIETHYL ACETAL 2-Phthalimidylacetaldehyde diethyl acetal 2-(Phthalimido)acetaldehyde diethylacetal 2-(2,2-diethoxyethyl)-1H-isoindole-1,3(2H)-dione
CAS	78902-09-7
InChI	InChI=1/C14H17NO4/c1-3-18-12(19-4-2)9-15-13(16)10-7-5-6-8-11(10)14(15)17/h5-8,12H,3-4,9H2,1-2H3

Phthalimidoacetaldehyde diethyl acetal - Physico-chemical Properties

Molecular Formula	C14H17NO4
Molar Mass	263.29
Density	1.200±0.06 g/cm3(Predicted)
Melting Point	72-74 °C (lit.)
Boling Point	372.3±32.0 °C(Predicted)
Flash Point	179°C
Water Solubility	Insoluble in water.
Vapor Presure	9.7E-06mmHg at 25°C
Appearance	powder to crystal
Color	Light yellow to Yellow to Orange
BRN	215793
pKa	-2.17±0.20(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Sensitive	Moisture Sensitive
Refractive Index	1.541
MDL	MFCD00005901
Physical and Chemical Properties	Off-white to white powder

Phthalimidoacetaldehyde diethyl acetal - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
HS Code	29126000
Hazard Note	Irritant

Phthalimidoacetaldehyde diethyl acetal - Reference Information

Application

the performance of phthalimide is relatively stable, n-H on the hydrogen is very active can be substituted by many groups to generate important organic chemical products, so that in pesticides, pharmaceuticals, dyes, organic pigments, rubber and other fields have a wide range of applications. Benzoyl iminoacetaldehyde diethyl acetal is its derivatives, also mainly used as pharmaceutical intermediates.

preparation

in a 250 mL Erlenmeyer flask add phthalic anhydride and aminoacetaldehyde diethanol acetal, iron powder and 100
mL water, mixed well. A reflux condenser tube was installed and irradiated with microwave (thin layer chromatography) until the reaction was complete. Cool to room temperature, Suction filtration, filter cake drying. The filtrate was extracted with ethyl acetate and petroleum ether respectively, the organic layer was separated, dried with anhydrous magnesium sulfate, and the extractant was removed by rotary evaporation to obtain a yellow needle-like solid. The filter cake was dissolved in an appropriate amount of hot DMF, and filtered while hot, the filter cake was washed with a small amount of hot DMF, and the filtrate was collected and dried over anhydrous magnesium sulfate. Then, DMF was recovered by distillation under reduced pressure to obtain a yellow needle-like solid. The yellow needle-like solid is combined to give the product phthaliminoacetaldehyde diethylacetal.

Last Update：2024-04-10 22:29:15